International Journal of Innovative Engineering, Technology & Science

Pharmaco-Kinetic Prediction of the Drug Distribution Profile in A Human Physiological System
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Pharmaco-Kinetic Prediction of the Drug Distribution Profile in A Human Physiological System

Publication Date : 12/05/2020


Author(s) :

Ikezue, E. N, Okeke, A. C, Okoye, J. O..


Volume/Issue :
Volume 3
,
Issue 1
(05 - 2020)



Abstract :

Drugs are medicinal substances that are administered mostly orally and then metabolized in the gastro-intestinal tract (G.I.T) and subsequently assimilated in the blood stream. The paper highlights computerized solutions of a simplified mathematical model that adequately simulates the drug distribution profile in a human physiological process. The result shows the mechanism or the process of absorption in the blood vessels X(t) and the initial build up in the G.I.T and predicts that the ingested drug concentration reduces exponentially in the G.I.T due to metabolic action and then starts from an infinitesimal amount in the blood stream and increases to a threshold value as it is being distributed to various parts of the human body.


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