PHARMACO-KINETIC PREDICTION OF THE DRUG DISTRIBUTION PROFILE IN A HUMAN PHYSIOLOGICAL SYSTEM

Ikezue, E. N.; Okeke, A. C.; Okoye, J. O.

Authors & affiliations

Ikezue, E. N.

Department of Chemical Engineering, Chukwuemeka Odumegwu Ojukwu University, Uli, Anambra State, Nigeria

Okeke, A. C.

Department of Chemical Engineering, Chukwuemeka Odumegwu Ojukwu University, Uli, Anambra State, Nigeria

Okoye, J. O.

Department of Chemical Engineering, Enugu State University of Science and Technology, Enugu, Enugu State Nigeria.

Abstract

Summary

Drugs are medicinal substances that are administered mostly orally and then metabolized in the gastro-intestinal tract
(G.I.T) and subsequently assimilated in the blood stream. The paper highlights computerized solutions of a simplified
mathematical model that adequately simulates the drug distribution profile in a human physiological process. The
result shows the mechanism or the process of absorption in the blood vessels X(t) and the initial build up in the G.I.T
and predicts that the ingested drug concentration reduces exponentially in the G.I.T due to metabolic action and then
starts from an infinitesimal amount in the blood stream and increases to a threshold value as it is being distributed to
various parts of the human body.

Keywords

Index Terms

Sublingual Pack Oesopharynx Gastro-intestinal Tract Transdermal Vena Cava Villi.

Citation & details

How to cite this article

Authors: Ikezue, E. N., Okeke, A. C., Okoye, J. O.

Volume/Issue: Volume 3, Issue 1

Pages: 1-6

Published: April 30, 2020

Affiliations: Department of Chemical Engineering, Chukwuemeka Odumegwu Ojukwu University, Uli, Anambra State, Nigeria, Department of Chemical Engineering, Enugu State University of Science and Technology, Enugu, Enugu State Nigeria.

Ikezue, E. N., Okeke, A. C., Okoye, J. O. (2020). PHARMACO-KINETIC PREDICTION OF THE DRUG DISTRIBUTION PROFILE IN A HUMAN PHYSIOLOGICAL SYSTEM. International Journal of Innovative Engineering, Technology & Science (IJIETS), Volume 3, Issue 1, 1-6.

Ikezue, E. N., Okeke, A. C., Okoye, J. O.. "PHARMACO-KINETIC PREDICTION OF THE DRUG DISTRIBUTION PROFILE IN A HUMAN PHYSIOLOGICAL SYSTEM." International Journal of Innovative Engineering, Technology & Science (IJIETS), vol. Volume 3, Issue 1, 2020, pp. 1-6.

Ikezue, E. N., Okeke, A. C., Okoye, J. O.. "PHARMACO-KINETIC PREDICTION OF THE DRUG DISTRIBUTION PROFILE IN A HUMAN PHYSIOLOGICAL SYSTEM." International Journal of Innovative Engineering, Technology & Science (IJIETS) Volume 3, Issue 1 (2020): 1-6.

@article{pharmacokineticpredictionofthedrugdistributionprofileinahumanphysiologicalsystem2020, author = {Ikezue, E. N. and Okeke, A. C. and Okoye, J. O.}, title = {PHARMACO-KINETIC PREDICTION OF THE DRUG DISTRIBUTION PROFILE IN A HUMAN PHYSIOLOGICAL SYSTEM}, journal = {International Journal of Innovative Engineering, Technology & Science (IJIETS)}, year = {2020}, volume = {Volume 3, Issue 1}, pages = {1-6} }

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